Viral rewiring of cellular lipid metabolism to create membranous replication compartments.
Identifieur interne : 000D41 ( Main/Exploration ); précédent : 000D40; suivant : 000D42Viral rewiring of cellular lipid metabolism to create membranous replication compartments.
Auteurs : Jeroen Rpm Strating [Pays-Bas] ; Frank Jm Van Kuppeveld [Pays-Bas]Source :
- Current opinion in cell biology [ 1879-0410 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Membrane cellulaire, Stérols.
- physiologie : Virus à ARN.
- virologie : Membrane cellulaire.
- Animaux, Humains, Métabolisme des lipides, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Sterols.
- metabolism : Cell Membrane.
- physiology : RNA Viruses.
- virology : Cell Membrane.
- Animals, Humans, Lipid Metabolism, Virus Replication.
Abstract
Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid metabolism. Disparate viruses have many commonalities as well as disparities in their interactions with the host lipidome and accumulate specific sets of lipids (sterols, glycerophospholipids, sphingolipids) at their VRCs. Recent years have seen an upsurge in studies investigating the role of lipids in +RNA virus replication, in particular of sterols, and uncovered that membrane contact sites and lipid transfer proteins are hijacked by viruses and play pivotal roles in VRC formation.
DOI: 10.1016/j.ceb.2017.02.005
PubMed: 28242560
Affiliations:
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Electronic address: j.strating@uu.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Utrecht University, Faculty of Veterinary Medicine, Department of Infectious Diseases & Immunology, Division of Virology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Van Kuppeveld, Frank Jm" sort="Van Kuppeveld, Frank Jm" uniqKey="Van Kuppeveld F" first="Frank Jm" last="Van Kuppeveld">Frank Jm Van Kuppeveld</name><affiliation wicri:level="4"><nlm:affiliation>Utrecht University, Faculty of Veterinary Medicine, Department of Infectious Diseases & Immunology, Division of Virology, Utrecht, The Netherlands. Electronic address: f.j.m.vankuppeveld@uu.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Utrecht University, Faculty of Veterinary Medicine, Department of Infectious Diseases & Immunology, Division of Virology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author></analytic><series><title level="j">Current opinion in cell biology</title><idno type="eISSN">1879-0410</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Membrane (metabolism)</term><term>Cell Membrane (virology)</term><term>Humans</term><term>Lipid Metabolism</term><term>RNA Viruses (physiology)</term><term>Sterols (metabolism)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Membrane cellulaire (métabolisme)</term><term>Membrane cellulaire (virologie)</term><term>Métabolisme des lipides</term><term>Réplication virale</term><term>Stérols (métabolisme)</term><term>Virus à ARN (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sterols</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Membrane cellulaire</term><term>Stérols</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus à ARN</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>RNA Viruses</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Membrane cellulaire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cell Membrane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lipid Metabolism</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Métabolisme des lipides</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Positive-strand RNA (+RNA) viruses (e.g. poliovirus, hepatitis C virus, dengue virus, SARS-coronavirus) remodel cellular membranes to form so-called viral replication compartments (VRCs), which are the sites where viral RNA genome replication takes place. To induce VRC formation, these viruses extensively rewire lipid metabolism. Disparate viruses have many commonalities as well as disparities in their interactions with the host lipidome and accumulate specific sets of lipids (sterols, glycerophospholipids, sphingolipids) at their VRCs. Recent years have seen an upsurge in studies investigating the role of lipids in +RNA virus replication, in particular of sterols, and uncovered that membrane contact sites and lipid transfer proteins are hijacked by viruses and play pivotal roles in VRC formation.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Utrecht (province)</li></region><settlement><li>Utrecht</li></settlement><orgName><li>Université d'Utrecht</li></orgName></list><tree><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Strating, Jeroen Rpm" sort="Strating, Jeroen Rpm" uniqKey="Strating J" first="Jeroen Rpm" last="Strating">Jeroen Rpm Strating</name></region><name sortKey="Van Kuppeveld, Frank Jm" sort="Van Kuppeveld, Frank Jm" uniqKey="Van Kuppeveld F" first="Frank Jm" last="Van Kuppeveld">Frank Jm Van Kuppeveld</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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